The major histocompatibility complex (MHC) of the water vole
Information is provided about the current state of knowledge on the MHC selection in the water Vole. - The slide-show (39 slides) reviews the MHC selection mechanisms at various time scales (contemporary, historical) as they are known in voles. Some detection methods are also overviewed. - four articles addressing focus aspects of the MHC selection are made available : . Bryja et al., 2006: Duplication, balancing selection and trans-species evolution explain the high levels of polymorphism of the DQA MHC class II gene in voles (Arvicolinae). . Bryja et al., 2007: Density-related changes in selection pattern for major histocompatibility complex genes in fluctuating populations of voles. . Deter et al., 2008: Association between the DQA MHC class II gene and Puumala virus infection in Myodes glareolus, the bank vole. . Tollenaere et al., 2008: Multiple parasites mediate balancing selection at two MHC class II genes in the fossorial water vole: insights from multivariate analyses and population genetics. - Generic Wiki article on MHC are also provided for convenience.