Identification of immunogenetic factors mediating rodent susceptibility to hantaviruses
|
This file deals with the following question : - Is it possible to identify factors mediating genetic susceptibility of rodents to hantaviruses - by studying the genes involved in the immune response - using phylogeny, phylogeography and population genetics ? The documents below provide three levels of information on rodents' susceptibility to hantaviruses, namely : [Article] 1.- A bibliographic review on hantavirus-induced immune responses in rodent reservoir (to help determine candidate genes) [Slideshow] 2.- A candidate gene approach applied over the macro-evolutive scale(between species) : the case of integrins. 3.- A candidate gene approach applied over the micro-evolutive scale (within species): the case of Mhc genes and Myodes glareolus at various scales : [Article] a) Experimental infection. [Article] b) 'Local' scale in Jura - France [Slideshow] c) Regional scale in Europe _